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Genistein significantly improves immediate recall, verbal learning, executive function, attention, and immediate visual memory and slows down amyloid-beta deposition in the anterior cingulate gyrus of patients with prodromal Alzheimer’s disease (AD), according to the results of the randomized, double-blind, placebo-controlled phase II GENIAL study.

Genistein may delay dementia onset in prodromal Alzheimer’s disease

Menopause occurs early among women with diabetes

Women appear to experience premature menopause in the presence of diabetes, according to a study.

Menopause occurs early among women with diabetes

09 Nov 2022

Bremelanotide enhances sexual brain processing in women with hypoactive sexual desire

A randomized, double-blind, placebo-controlled, crossover clinical study has found that a single subcutaneous injection of bremelanotide significantly increases sexual desire for up to 24 hours through enhancing sexual brain processing in women with hypoactive sexual desire disorder (HSDD).

Bremelanotide enhances sexual brain processing in women with hypoactive sexual desire

Atezolizumab bests chemo in advanced NSCLC

First-line immunotherapy treatment with atezolizumab – a PD-L1 inhibitor – offers a survival advantage over single-agent chemotherapy in patients with advanced non-small cell lung cancer (NSCLC) who are ineligible for platinum doublets in the phase III IPSOS trial.

Atezolizumab bests chemo in advanced NSCLC

TIL therapy improves PFS in patients with advanced melanoma

Tumour-infiltrating lymphocyte therapy significantly improved progression-free survival (PFS) in patients with advanced melanoma compared with standard-of-care treatment with ipilimumab, according to the M14TIL trial presented at ESMO 2022.

TIL therapy improves PFS in patients with advanced melanoma

Is vonoprazan an alternative to pantoprazole in preventing post-EVL ulcers, bleeding?

08 Nov 2022 bởi

Vonoprazan may be as effective as pantoprazole in reducing the risk of ulcers or bleeding following endoscopic variceal ligation (EVL) in patients with portal hypertension, according to a small study from Egypt presented at the United European Gastroenterology Week (UEG 2022).

Is vonoprazan an alternative to pantoprazole in preventing post-EVL ulcers, bleeding?

Ticagrelor–aspirin more effective in patients with normal vs impaired renal function

Patients with normal, instead of impaired, renal function tend to benefit more from the combination therapy ticagrelor plus aspirin than clopidogrel plus aspirin, reveals a study.

Ticagrelor–aspirin more effective in patients with normal vs impaired renal function

CRP, procalcitonin predict infections in febrile infants

08 Nov 2022 bởi

Biomarkers such as C-reactive protein (CRP) and procalcitonin are robust predictors of serious bacterial infections (SBIs) and invasive bacterial infections (IBIs), respectively, in febrile infants, results of a Singapore study have shown.

CRP, procalcitonin predict infections in febrile infants

Low vitamin D levels up mortality risk in adults

A deficiency in vitamin D levels appears to increase the risk of death in adults, suggests a study.

Low vitamin D levels up mortality risk in adults

EDS device with fluticasone cuts CRS exacerbations

08 Nov 2022 bởi

The use of an exhalation delivery system with fluticasone (EDS-FLU) significantly reduces acute exacerbations of chronic rhinosinusitis (CRS), which may help drive down the need for antibiotics and prevent antibiotic resistance, in the ReOpen1 and 2 randomized controlled trials.

EDS device with fluticasone cuts CRS exacerbations