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The use of selective dorsal neurectomy (SDN)/cryoablation (CA) as a treatment option for patients with premature ejaculation remains controversial, according to a study. SDN/CA affects intravaginal ejaculatory latency time (IELT) and patient satisfaction.

Is selective dorsal neurectomy/cryoablation effective for premature ejaculation?

Short-term exposure to ozone air pollution ups risks of hospital admissions for MI, stroke

Individuals with short-term exposure to ozone (O3) air pollution are at risk of myocardial infarction (MI) and stroke requiring hospitalization, according to a systematic review and meta-analysis.

Short-term exposure to ozone air pollution ups risks of hospital admissions for MI, stroke

Thumbs up for rucaparib maintenance across prognostic subgroups of HRD-negative ovarian cancer

06 Sep 2025 bởi

Maintenance with the PARP inhibitor rucaparib after first-line platinum-doublet chemotherapy and cytoreductive surgery appears to reduce the risk of progression in the homologous recombination deficiency (HRD)-negative population of patients with advanced, high-grade ovarian cancer enrolled in the phase III ATHENA-MONO trial, no matter the prognostic factor.

Thumbs up for rucaparib maintenance across prognostic subgroups of HRD-negative ovarian cancer

Chlorthalidone trumps HCTZ for stone prevention; morning dosing preferable

06 Sep 2025 bởi

Calcium stone formers prefer the long-acting and more effective chlorthalidone for stone prevention, reports a study. The time of administration appears irrelevant, but morning administration may be more effective in addressing higher postdinner calcium excretion.

Chlorthalidone trumps HCTZ for stone prevention; morning dosing preferable

Teens with dysmenorrhea prone to chronic pain as adults

Dysmenorrhoea in adolescence appears to contribute to an increased risk of chronic pain in adulthood, according to a study.

Teens with dysmenorrhea prone to chronic pain as adults

Selinexor maintenance shows consistent benefit in TP53wt endometrial cancer

06 Sep 2025 bởi

Selinexor maintenance therapy continues to show consistent clinical benefit in patients with TP53 wild-type (TP53wt) advanced or recurrent endometrial cancer, regardless of mismatch repair (MMR) status, according to the ENGOT-EN5/GOG-3055/SIENDO trial presented at ESMO Gyn 2025.

Selinexor maintenance shows consistent benefit in TP53wt endometrial cancer

What stops patients in SG from getting surgery for drug-resistant epilepsy?

05 Sep 2025 bởi

Many people with drug-resistant epilepsy in Singapore do not consider surgery because of the overestimated risk of the surgical procedure and the perception that seizures are nondisabling, according to a local cross-sectional survey study.

What stops patients in SG from getting surgery for drug-resistant epilepsy?

Which factors influence sexual abstinence among young people?

A recent systematic review has found varying prevalence of sexually abstinent adolescents and young adults across studies, as well as a range of factors and motivations or barriers shaping sexual abstinence.

Which factors influence sexual abstinence among young people?

First-line durvalumab plus tremelimumab safe to use in unresectable HCC

05 Sep 2025 bởi

The phase IIIb SIERRA study has shown an acceptable safety profile for the single tremelimumab regular interval durvalumab (STRIDE) regimen as first-line treatment for patients with hepatocellular carcinoma (HCC) who have a poor prognosis.

First-line durvalumab plus tremelimumab safe to use in unresectable HCC

05 Sep 2025

One functioning kidney insufficient to tell reduced renal reserve in boys with PUV

Boys with posterior urethral valves (PUV) may find it difficult to address decreased renal reserve with only one functioning kidney on a dimercaptosuccinic acid (DMSA) scan, suggests a study.

One functioning kidney insufficient to tell reduced renal reserve in boys with PUV