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Implementing a pharmacist-driven protocol of second-dose cefepime results in a lower duration between second-dose antibiotics, days requiring vasopressors, and a slight decrease in length of hospital stay among adult patients with sepsis in the emergency department (ED), according to a study.

Pharmacist-led two-dose cefepime protocol a boon for sepsis patients

Can neurologic manifestations predict poor outcomes in young SARS-CoV-2, MIS-C patients?

A prospective cohort study has shown that in patients aged <18 years hospitalized for acute SARS-CoV-2-related multisystem inflammatory syndrome in children (MIS-C), neurologic manifestations during the infection are common and may predispose them more to new neurocognitive or functional morbidity at discharge.

Can neurologic manifestations predict poor outcomes in young SARS-CoV-2, MIS-C patients?

03 Oct 2024

Mailed intervention cuts sedative use and improves sleep in the elderly

A simple, scalable, direct-to-patient intervention consisting of two booklets and a website substantially reduced benzodiazepine receptor agonist (BZRA) use and improved sleep outcomes in older adults, the randomized YAWNS NB trial has shown.

Mailed intervention cuts sedative use and improves sleep in the elderly

Metoclopramide of no help in improving pneumonia, functional outcomes in select stroke patients

For patients who have been placed on a nasogastric tube shortly after stroke onset, a 4-day treatment course of metoclopramide does not appear to have any effect on the incidence of pneumonia or functional outcomes, according to data from the PRECIOUS trial.

Metoclopramide of no help in improving pneumonia, functional outcomes in select stroke patients

The FINEART of finerenone: A new option for HFmrEF/HFpEF?

Full results of the phase III FINEARTS-HF trial have shown that finerenone cuts the risk of worsening heart failure (HF) events and cardiovascular (CV) death in symptomatic HF with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF).

The FINEART of finerenone: A new option for HFmrEF/HFpEF?

Novel AI tool for predicting cardio-cerebrovascular disease risk among Chinese

Researchers at the University of Hong Kong (HKU) have developed an innovative artificial intelligence (AI) assessment model that has the potential to fundamentally change the prevention and management of cardio-cerebrovascular (CCV) diseases specifically in the Chinese population.

Novel AI tool for predicting cardio-cerebrovascular disease risk among Chinese

03 Oct 2024

Epilepsy and ASM use in pregnancy increase morbidity and mortality risks in women and their offspring

Women with epilepsy are at considerably higher risk of severe maternal and perinatal outcomes and increased risk of death during pregnancy and postpartum, and the use of antiseizure medications (ASM) further increases these risks, the largest study to date has found.

Epilepsy and ASM use in pregnancy increase morbidity and mortality risks in women and their offspring

03 Oct 2024

Wearable device-based exercise intervention improves activity levels after lung cancer surgery

In patients who are undergoing a surgical procedure for lung cancer, perioperative exercise interventions using wearable devices may help increase physical activity and improve dyspnoea after the procedure when compared with usual care, according to a study.

Wearable device-based exercise intervention improves activity levels after lung cancer surgery

Crisugabalin for postherpetic neuralgia scores high in phase III trial

02 Oct 2024 bởi

The oral calcium channel α2δ-1 subunit ligand crisugabalin appears to provide relief for patients with postherpetic neuralgia, significantly reducing average daily pain scores as compared with placebo, as shown in a phase III trial.

Crisugabalin for postherpetic neuralgia scores high in phase III trial

Surrogate mothers at high risk of morbidity, adverse pregnancy outcomes

Gestational carriers, or surrogate mothers, are at increased risk for severe maternal morbidity (SMM) and adverse pregnancy outcomes than women who conceived with and without assistance, reports a recent study.

Surrogate mothers at high risk of morbidity, adverse pregnancy outcomes