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Inhibition of angiopoietin-like 3 (ANGPTL-3) with SHR-1918 leads to further low-density lipoprotein cholesterol (LDL-C) reductions in patients at increased risk of atherosclerotic cardiovascular disease (ASCVD), a phase II study has shown.

Novel agent lowers LDL-C in ASCVD at-risk patients

Temocillin a good alternative to carbapenems for bacteraemia

The use of temocillin demonstrates comparable efficacy and safety to carbapenems for the targeted treatment of bacteraemia due to third-generation cephalosporin-resistant Enterobacterales (3GCR-E), primarily from urinary sources, reports a study.

Temocillin a good alternative to carbapenems for bacteraemia

5-day antibiotic use viable in CAP patients with clinical stability

Antibiotic treatment may be done for 5 days, as opposed to at least 7 days, in hospitalized patients with community-acquired pneumonia (CAP) who had achieved clinical stability by day 3 to 5, suggests a study presented at ESCMID Global 2025.

5-day antibiotic use viable in CAP patients with clinical stability

16 May 2025

Updated EPIC-HR data bolster nirmatrelvir/ritonavir role against COVID-19

Updated data from the EPIC-HR* trial show reduced duration of COVID-19 symptoms and utilization of healthcare resources with nirmatrelvir/ritonavir (NMV/r) in high-risk, unvaccinated, nonhospitalized, symptomatic adults with COVID-19.

Updated EPIC-HR data bolster nirmatrelvir/ritonavir role against COVID-19

16 May 2025

Extended caffeine treatment for apnoea in preemies offers little benefit

Continuation of caffeine treatment for apnoea in moderately preterm infants does not help shorten hospitalization, according to a study.

Extended caffeine treatment for apnoea in preemies offers little benefit

Linaclotide improves bowel symptoms in children with functional constipation

Treatment with linaclotide led to significantly improved symptoms of incomplete bowel evacuation and straining in paediatric patients aged 6–17 years with functional constipation, according to a phase III study presented at DDW 2025.

Linaclotide improves bowel symptoms in children with functional constipation

Starting DOACs sooner after stroke may be best for AF patients

15 May 2025 bởi

For secondary stroke prevention in patients with atrial fibrillation (AF), the optimal timing of initiating a direct oral anticoagulant (DOAC) remains elusive, although evidence from a phase II study suggests that earlier initiation is better than later times within the first 2 weeks after stroke onset.

Starting DOACs sooner after stroke may be best for AF patients

Tirzepatide eases MetS, cardiometabolic abnormalities in T2D

Individuals with type 2 diabetes (T2D) may benefit from using tirzepatide, which has been shown in a recent study to improve cardiometabolic abnormalities and resolve metabolic syndrome (MetS).

Tirzepatide eases MetS, cardiometabolic abnormalities in T2D

Intakes of nonfermented milk, cheese may raise T2D risk

15 May 2025 bởi

Adults with high intakes of nonfermented milk and cheese appear to be at greater risk of developing type 2 diabetes (T2D), while those who consume fermented milk, cream, and butter show a lower risk, according to a study.

Intakes of nonfermented milk, cheese may raise T2D risk

15 May 2025

CAR T-cell therapy improves survival in non-Hodgkin lymphoma

Treatment with chimeric antigen receptor T-cell therapies (CAR-TCT) results in significant improvements in overall (OS) and progression-free survival (PFS) among patients with refractory non-Hodgkin lymphoma (NHL) but shows no substantial effect on event-free survival (EFS), reports a study.

CAR T-cell therapy improves survival in non-Hodgkin lymphoma