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Heparin unable to prevent miscarriages in women with inherited thrombophilia

01 Jul 2023 bởi

Daily shots of low-molecular weight heparin (LMWH) fall short of improving live birth rates for women with a history of at least two pregnancy losses and inherited thrombophilia, according to the results of the open-label trial ALIFE2.

Heparin unable to prevent miscarriages in women with inherited thrombophilia

01 Jul 2023

Early menopause, premature ovarian insufficiency spell increased dementia risk

01 Jul 2023

Early menopause or premature ovarian insufficiency may put women at increased risk of dementia, as reported in a recent study.

Early menopause, premature ovarian insufficiency spell increased dementia risk

01 Jul 2023

Original New Drug Application Approvals by US FDA (16-30 June 2023)

01 Jul 2023

New drug applications approved by US FDA as of 16-30 June 2023 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (16-30 June 2023)

01 Jul 2023

Heavy coffee drinking may increase abdominal aortic calcification for some

30 Jun 2023

Adults with hypertension, diabetes, and cardiovascular diseases may benefit from cutting back on coffee, especially the caffeinated variant, which has been shown to increase the burden of abdominal aortic calcification in a study.

Heavy coffee drinking may increase abdominal aortic calcification for some

30 Jun 2023

Another IBAT inhibitor makes its case in large PFIC trial

30 Jun 2023 bởi

The ileal bile acid transporter (IBAT) inhibitor maralixibat appears to quell itching and reduce serum bile acid concentration in children with progressive familial intrahepatic cholestasis (PFIC), while having a tolerable safety profile, according to data from the phase III MARCH-PFIC trial said to be the largest to date.

Another IBAT inhibitor makes its case in large PFIC trial

30 Jun 2023

Renal mass biopsy mandate tied to fewer surgeries, greater surveillance

30 Jun 2023

Implementation of the mandate on preablation renal mass biopsy appears to result in the wider use of biopsies for all small renal mass patients, fewer surgical interventions, and an increase in active surveillance, reports a recent study.

Renal mass biopsy mandate tied to fewer surgeries, greater surveillance

30 Jun 2023

Pembrolizumab plus gemcitabine/cisplatin improves survival in metastatic biliary tract cancer

30 Jun 2023 bởi

Treatment with pembrolizumab (pembro) in combination with gemcitabine and cisplatin (gem/cis) results in a statistically significant, clinically meaningful improvement in overall survival (OS) when compared with placebo plus gem/cis in patients with previously untreated metastatic or unresectable biliary tract cancer (BTC), results of the KEYNOTE-966 study have shown.

Pembrolizumab plus gemcitabine/cisplatin improves survival in metastatic biliary tract cancer

30 Jun 2023

Poor sleep quality ups risk of sexual dysfunction

30 Jun 2023

Sleep disorders, particularly obstructive sleep apnoea, are associated with a higher risk of sexual dysfunction (SD) in both men and women, suggests a study.

Poor sleep quality ups risk of sexual dysfunction

30 Jun 2023

Long-term data support teduglutide safety for SBS-IF

30 Jun 2023 bởi

In a pooled analysis of two long-term paediatric extension trials evaluating short bowel syndrome-associated intestinal failure (SBS-IF), the glucagon-like peptide-2 analogue teduglutide (TED) demonstrated a safety profile that aligned with previous data.

Long-term data support teduglutide safety for SBS-IF

30 Jun 2023

Does vitamin D therapy improve survival in patients with CKD?

30 Jun 2023

For patients with chronic kidney disease (CKD), vitamin D therapy does little to reduce the risk of all-cause death, according to a study.

Does vitamin D therapy improve survival in patients with CKD?

30 Jun 2023

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Heparin unable to prevent miscarriages in women with inherited thrombophilia

Heparin unable to prevent miscarriages in women with inherited thrombophilia

Early menopause, premature ovarian insufficiency spell increased dementia risk

Early menopause, premature ovarian insufficiency spell increased dementia risk

Original New Drug Application Approvals by US FDA (16-30 June 2023)

Original New Drug Application Approvals by US FDA (16-30 June 2023)

Heavy coffee drinking may increase abdominal aortic calcification for some

Heavy coffee drinking may increase abdominal aortic calcification for some

Another IBAT inhibitor makes its case in large PFIC trial

Another IBAT inhibitor makes its case in large PFIC trial

Renal mass biopsy mandate tied to fewer surgeries, greater surveillance

Renal mass biopsy mandate tied to fewer surgeries, greater surveillance

Pembrolizumab plus gemcitabine/cisplatin improves survival in metastatic biliary tract cancer

Pembrolizumab plus gemcitabine/cisplatin improves survival in metastatic biliary tract cancer

Poor sleep quality ups risk of sexual dysfunction

Poor sleep quality ups risk of sexual dysfunction

Long-term data support teduglutide safety for SBS-IF

Long-term data support teduglutide safety for SBS-IF

Does vitamin D therapy improve survival in patients with CKD?

Does vitamin D therapy improve survival in patients with CKD?