Alzheimer's Disease & Dementia Disease Summary

Last updated: 07 January 2026

Overview

Dementia and Alzheimer’s Disease are terms that are usually interchanged. In the Introduction section, this will be clarified.

There are millions of people affected by Alzheimer’s disease regionally and worldwide. Details on the number of individuals affected are in the Epidemiology section.

There are many causes of Alzheimer’s disease. The Etiology section enumerated these causes. The complex and multifactorial pathophysiology of Alzheimer’s disease is discussed in the Pathophysiology section.

The modifiable and non-modifiable risk factors of Alzheimer’s disease are enumerated in the Risk Factors section, while the different types of Alzheimer’s disease are discussed in the Classification section. 

History and Physical Examination

The Clinical Presentation and History sections detail the cognitive and other manifestations of Alzheimer's disease. The Physical Examination section mentions the neurologic assessment needed to rule out treatable causes of the disease.

Diagnosis

Diagnostic criteria in diagnosing Alzheimer's disease are in the Diagnosis or Diagnostic Criteria section.

The Screening, Laboratory Tests and Ancillaries and Imaging sections enumerate the tests that can be performed in assessing and evaluating the effect of the disease on the patient.

Other diseases to be considered which present similarly are in the Differential Diagnosis section.

Management

There are several drugs that can be considered in the management of cognitive and neuropsychiatric symptoms of Alzheimer’s disease and they are enumerated and discussed in the Pharmacological Therapy section.

Several supportive measures and psychotherapies can be given to patients with Alzheimer’s disease and the Nonpharmacological section explains each one.

The Prevention section enumerates the ways to prevent the disease through the modifiable risk factors identified. 

Frequently Asked Questions

How is Alzheimer’s disease dementia clinically diagnosed?
Alzheimer’s disease dementia is diagnosed primarily through clinical assessment using standard diagnostic criteria. Evaluation should include medical, psychiatric, neurological, medication and social history, with cognitive and behavioral information from the patient and caregiver. MRI findings such as hippocampal or global cortical atrophy may support the diagnosis. Read more
Which tests support dementia evaluation?
Recommended evaluation may include CBC, serum electrolytes, liver and renal function tests, glucose, thyroid function tests, vitamin B12, folate, and syphilis serology if suspected. EEG may be useful when Creutzfeldt-Jakob disease, seizures, or delirium is considered. Read more
When are cholinesterase inhibitors appropriate?
Cholinesterase inhibitors should be considered across all stages of Alzheimer’s disease. Donepezil, galantamine and rivastigmine enhance central cholinergic function and may improve cognitive, behavioral and functional measures. Read more
When is memantine used in Alzheimer’s disease?
Memantine is used for moderate to severe Alzheimer’s disease as a noncompetitive NMDA-receptor antagonist. It may also be used as monotherapy in mild to moderate disease when cholinesterase inhibitors are contraindicated, not tolerated, or when disease progresses despite an adequate trial. Read more
What non-pharmacological support helps dementia care?
Non-pharmacological care should be individualized to maintain cognition, function, independence and well-being. Useful measures include patient and caregiver education, simple instructions, consistent routines, orientation cues, caregiver support, respite care, psychotherapy and functional training. Read more