Pneumonia - Community-Acquired Disease Summary

Last updated: 30 January 2026

Overview

Pneumonia is an acute infection of the pulmonary parenchyma accompanied by symptoms of acute illness and abnormal chest findings. It is further described in the Introduction section.

Pneumonia is still the leading cause of death from an infectious disease in adults and children. A detailed discussion about the prevalence of pneumonia in the region is in the Epidemiology section.

The most frequently isolated organism in patients with community-acquired pneumonia is Streptococcus pneumoniae. Other commonly identified pathogens are enumerated in the Etiology section.  

The Pathophysiology section identifies the mechanisms involved when a patient is infected with pneumonia. The section also mentions the virulence factors of some of the causative agents of community-acquired pneumonia.

The Risk Factors section identifies the various circumstances predisposing an individual to acquiring community-acquired pneumonia.

Depending on the patient’s overall clinical status, vital signs, presence of co-morbidities, and chest X-ray findings, the patient may be classified to have low-, moderate- or high-risk community-acquired pneumonia.  The Classification section describes each of these types.

History and Physical Examination

The Clinical Presentation section describes the respiratory symptoms and other signs and symptoms of patients with community-acquired pneumonia. This section also discusses the typical presentation of each type of community-acquired pneumonia.

Diagnosis

In the Diagnosis and Diagnostic Criteria section, factors to consider in the definite diagnosis of community-acquired pneumonia are identified.

Several laboratory tests and imaging procedures serve as adjuncts in diagnosing pneumonia and they are enumerated in the Laboratory Tests and Ancillaries and Imaging sections.

Other diseases that can present with the same symptoms as pneumonia are listed in the Differential Diagnosis section.

Management

Patients with severe community-acquired pneumonia should be managed in a hospital setting. Indications for direct intensive care unit (ICU) admission are discussed in the Evaluation section. In this section also risk assessment and severity index tests are further elaborated.

Factors to consider in the treatment of patients with community-acquired pneumonia are in the Principles of Therapy section.

The Pharmacological Therapy section discusses in detail the recommended empiric antibiotic therapy and the duration of therapy based on etiology. Some of the supportive therapies are also mentioned.

The Nonpharmacological section includes things to educate the patient about the management of community-acquired pneumonia.  

Pneumococcal and influenza vaccines are employed in the prevention of community-acquired pneumonia. Details on these vaccines as well as smoking cessation are in the Prevention section.

The Monitoring section identifies the things to monitor for each type of pneumonia and discusses further treatment failure and criteria for discharge.  

Frequently Asked Questions

How is community-acquired pneumonia diagnosis confirmed?
Patients suspected of community-acquired pneumonia should undergo chest X-ray to establish the diagnosis and identify complications such as pleural effusion or multilobar disease. A definite diagnosis is based on compatible clinical features together with chest X-ray evidence of lung shadowing that is likely to be new and not attributable to another cause. Read more  
When should blood cultures be obtained in CAP?
Pretreatment blood cultures are recommended in severe community-acquired pneumonia, when empiric treatment for MRSA or Pseudomonas aeruginosa is being given, or when there is previous infection with either pathogen. They are also recommended in patients recently hospitalized and given parenteral antibiotics. At least two sets of pretreatment blood cultures should be obtained when indicated. Read more
How is CAP severity assessed for site of care?
Clinical judgment together with a validated prediction rule should guide the site-of-care decision. CRB65 may be used in primary care, while CURB65 may be used in patients presenting to hospital. A CRB65 score ≥2 should prompt hospital evaluation, while a CURB65 score ≥3 supports inpatient care and evaluation for intensive care. Other clinical, functional and social factors should also be considered. Read more
Which antibiotics are used for low-risk community-acquired pneumonia?
For low-risk outpatients without comorbidities or risk factors for methicillin-resistant Staphylococcus aureus or Pseudomonas aeruginosa, recommended empiric options include Amoxicillin or Doxycycline. A macrolide may be considered where local pneumococcal resistance is below 25%. Patients with comorbid illness may require combination therapy with Amoxicillin/clavulanate or a cephalosporin plus a macrolide or Doxycycline, or respiratory fluoroquinolone monotherapy. Read more  
When can intravenous antibiotics be switched to oral therapy?
Oral antibiotics should be used initially when they are tolerated and disease severity does not require intravenous therapy. Patients receiving intravenous antibiotics may be switched to oral treatment after 48 hours when clinically stable. Antibiotic selection should consider local antimicrobial resistance, and a different antibiotic class should be used when the patient has had recent antibiotic exposure. Read more