66th American Society of Hematology Annual Meeting and Exposition (ASH 2024)
San Diego, California, US 07 December 2024 - 10 December 2024
Add-on ibrutinib ENRICHes rituximab treatment effect for previously untreated MCL
In the phase II/III ENRICH trial, first-line (1L) ibrutinib with rituximab (IR) demonstrates superiority over rituximab plus chemotherapy (R-chemo; either R-CHOP* or bendamustine**-R) in older patients with previously untreated mantle cell lymphoma (MCL).
Add-on ibrutinib ENRICHes rituximab treatment effect for previously untreated MCL
21 Jan 2025
CAR T-cell therapy may overcome poor prognosis tied to conventional tiNHL therapies
A real-world study presented at ASH 2024 shows that CD19 chimeric antigen receptor (CAR) T-cell therapy is highly effective and has an acceptable toxicity profile for individuals with transformed indolent non-Hodgkin lymphoma (tiNHL).
CAR T-cell therapy may overcome poor prognosis tied to conventional tiNHL therapies
17 Jan 2025
Acalabrutinib-venetoclax hits mark for fit TN CLL patients
The interim analysis of the AMPLIFY trial provides the first phase III evidence of fixed-duration therapy combining a second-generation Bruton tyrosine kinase inhibitor (BTKi) with venetoclax with or without anti-CD20 for treatment-naïve (TN) chronic lymphocytic leukaemia (CLL).
Acalabrutinib-venetoclax hits mark for fit TN CLL patients
14 Jan 2025
Pirtobrutinib scores a phase III win in BTKi-pretreated CLL/SLL
The first phase III trial of pirtobrutinib in haematologic malignancies to readout has demonstrated superiority over investigator's choice in delaying progression in pretreated chronic lymphocytic leukaemia or small lymphocytic lymphoma (CLL/SLL), with results from the BRUIN CLL-321 study first presented at ASH 2024.
