Transforming outcomes in patients with FLT3-mutated AML
14 Aug 2025
byDr. Richard Dillon, Guy’s Hospital, King’s College London, London, UK
Due to its aggressive nature, high relapse rates, and poor survival outcomes, acute myeloid leukaemia (AML) with FMS-like tyrosine kinase 3 (FLT3) gene mutation continues to present significant treatment challenges despite use of targeted therapy. At an industry-sponsored meeting, Dr Richard Dillon from Guy’s Hospital, King’s College London, London, UK, reviewed evolving management practices for patients with FLT3-mutated AML, including unmet needs in the first-line and relapsed/refractory (R/R) settings, and discussed the role of measurable residual disease (MRD)–guided intervention.