Constipation in Adults - Chronic, Functional References

Last updated: 23 July 2026
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  1. Chinese Society of Gastroenterology & Chinese Medical Association. Consensus on the guidelines for the diagnosis and treatment of chronic constipation. Chin J Dig Dis. 2004;5(3):134-137. PMID: 15612250
  2. MedWormhttp://www.medworm.com/rss/index.php/Gastroenterology/17/http://www.medworm.com/rss/medicalfeeds/specialities/Gastroenterology.xml
  3. Gwee KA, Ghoshal UC, Gonlachanvit S, et al. Primary care management of chronic constipation in Asia: the ANMA chronic constipation tool. J Neurogastroenterol Motil. 2013 Apr;19(2):149-160. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644651/pdf/jnm-19-149.pdf. Accessed 28 Jan 2014. PMID: 23667746
  4. Camilleri M. Disorders of gastrointestinal motility. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016. https://www.clinicalkey.com. Accessed 18 Jan 2016:888-889.
  5. Sabrado CW, Neto IJFC, Pinto RA, et al. Diagnosis and treatment of constipation: a clinical update based on the Rome IV criteria. Journal of Coloproctology. 2018 Apr-Jun;38(2):137-144. https://doi.org/10.1016/j.jcol.2018.02.003. Accessed 29 May 2018
  6. Bharucha AE, Lacy BE. Mechanisms, evaluation, and management of chronic constipation. Gastroenterology. 2020 Apr;158(5):1232-1249.e3. doi: 10.1053/j.gastro.2019.12.034. Accessed 19 Nov 2020. PMID: 31945360
  7. Rao SSC. Constipation in the older adult. UpToDate. https://www.uptodate.com. 20 May 2020. Accessed 19 Nov 2020.
  8. Andresen V, Layer P. Medical therapy of constipation: current standards and beyond. Visc Med. 2018 Apr;34(2):123-127. doi: 10.1159/000488695. Accessed 23 Jun 2021. PMID: 29888241
  9. Aziz A, Whitehead WE, Palsson OS, et al. An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Expert Rev Gastroenterol Hepatol. 2020 Jan;14(1):39-46. doi: 10.1080/17474124.2020.1708718. Accessed 23 Jun 2021. PMID: 31893959
  10. Black CJ, Ford AC. Chronic idiopathic constipation in adults: epidemiology, pathophysiology, diagnosis and clinical management. Med J Aust. 2018 Jul;209(2):86-91. doi: 10.5694/mja18.00241. Accessed 23 Jun 2021. PMID: 29996755
  11. Lacy BE. Update on the management of chronic idiopathic constipation. Am J Manag Care. 2019 Mar;25(Suppl 4):S55-S62. Accessed 23 Jun 2021. PMID: 31002489
  12. Wu JCY, Chan AOO, Cheung TK, et al. Consensus statements on diagnosis and management of chronic idiopathic constipation in adults in Hong Kong. Hong Kong Med J. 2019 Apr;25(2):142-148. doi: 10.12809/hkmj187692. Accessed 23 Jun 2021. PMID: 30971503
  13. Ratnasingham K, Lo T, Jamal K, et al. The role of colonoscopy and CT colonography in patients presenting with symptoms of constipation. Br J Radiol. 2017 May;90(1073):20160147. doi: 10.1259/bjr.20160147. Accessed 16 Aug 2021. PMID: 28256902
  14. Serra J, Pohl D, Azpiroz F, et al. European Society of Neurogastroenterology and Motility guidelines on functional constipation in adults. Neurogastroenterol Motil. 2020 Feb;32(2):e13762. doi: 10.1111/nmo.13762. Accessed 16 Nov 2021. PMID: 31756783
  15. Araujo MM, Botelho PB. Probiotics, prebiotics, and synbiotics in chronic constipation: outstanding aspects to be considered for the current evidence. Front Nutr. 2022 Dec 8;9:935830. doi: 10.3389/fnut.2022.935830. PMID: 36570175
  16. Milosavljevic T, Popovic DD, Mijac DD, et al. Chronic constipation: gastroenterohepatologist's approach. Dig Dis. 2022;40(2):175-180. doi: 10.1159/000516976. PMID: 33946065
  17. Mitelmão FCR, Häckel K, Bergamaschi CDC, et al. The effect of probiotics on functional constipation in adults: a randomized, double-blind controlled trial. Medicine (Baltimore). 2022 Oct 28;101(43):e31185. doi: 10.1097/MD.0000000000031185. PMID: 36316826
  18. Sola KF, Vladimir-Knezevic S, Hrabac P, et al. The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. Eur J Clin Nutr. 2022 Dec;76(12):1675-1681. doi: 10.1038/s41430-022-01189-0. PMID: 35927504
  19. Chang L, Chey WD, Imdad A, et al. American Gastroenterological Association-American College of Gastroenterology clinical practice guideline: pharmacological management of chronic idiopathic constipation. Gastroenterology. 2023 Jun;164(7):1086-1106. doi: 10.1053/j.gastro.2023.03.214. PMID: 37211380
  20. Cho YS, Lee YJ, Shin JE, et al. 2022 Seoul consensus on clinical practice guidelines for functional constipation. J Neurogastroenterol Motil. 2023 Jul 30;29(3):271-305. doi: 10.5056/jnm23066. PMID: 37417257
  21. Ihara E, Manabe N, Ohkubo H, et al. Evidence-based clinical guidelines for chronic constipation 2023. Digestion. 2025;106(1):62-89. doi: 10.1159/000540912. PMID: 39159626
  22. Chen Z, Peng Y, Shi Q, et al. Prevalence and risk factors of functional constipation according to the Rome Criteria in China: a systematic review and meta-analysis. Front Med (Lausanne). 2022 Feb;9:815156. doi: 10.3389/fmed.2022.815156. PMID: 35252254
  23. Du X, Liu S, Jia P, et al. Epidemiology of constipation in elderly people in parts of China: a multicenter study. Front Public Health. 2022 Jun;10:823987. doi: 10.3389/fpubh.2022.823987. PMID: 35784241
  24. Lee YY, Kamani L, Piscoya A, et al. A global cascade approach to diagnosis and management of chronic constipation. World Gastroenterology Organisation (WGO). https://www.worldgastroenterology.org. 2025.
  25. Corsetti M, Shin A, Lacy BE, et al. Bowel disorders. Gastroenterology. 2026 May;170(6):1261-1282. doi: 10.1053/j.gastro.2026.02.003. Accessed 03 Jul 2026. PMID: 41713703