Content:
Overview
Content on this page:
Overview
Content on this page:
Overview
Overview
Acute uncomplicated urinary tract infection (UTI) is one of the most common bacterial infections in adults that may involve the lower and/or upper urinary tract.
Acute uncomplicated cystitis is an infection limited to the lower urinary tract while acute uncomplicated pyelonephritis is an infection that involves the upper urinary tract (renal parenchyma and pelvicaliceal system) that usually has significant bacteriuria.
Recurrent UTI is characterized by ≥2 culture-proven episodes of uncomplicated and/or complicated UTI in the last 6 months or ≥3 episodes with positive cultures in the last 12 months in patients with no structural or functional urinary tract abnormalities.
Selection of antimicrobial agent will depend on local sensitivity patterns of uropathogens, whether or not the patient is hospitalized, and the relative costs of therapy.
In cases where local resistance patterns are not known, empirical therapy should include initial intravenous dose of a long-acting parenteral antimicrobial agent and starting with a broader-spectrum agent and then narrowing the therapy when laboratory results are available.Patients with signs of urosepsis should be given empiric antimicrobial therapy with coverage for extended spectrum β-lactamase (ESBL)-producing organisms. Oral therapy should always be considered in patients with mild to moderate symptoms.Parenteral therapy should be used in patients who are too ill to take oral antibiotics, then switch to oral therapy once tolerated. Patient should be treated for a total of 7-14 days.
For further information regarding the management of Urinary Tract Infection - Uncomplicated, please refer to Disease Algorithm for the Treatment Guideline.
Acute uncomplicated cystitis is an infection limited to the lower urinary tract while acute uncomplicated pyelonephritis is an infection that involves the upper urinary tract (renal parenchyma and pelvicaliceal system) that usually has significant bacteriuria.
Recurrent UTI is characterized by ≥2 culture-proven episodes of uncomplicated and/or complicated UTI in the last 6 months or ≥3 episodes with positive cultures in the last 12 months in patients with no structural or functional urinary tract abnormalities.
Selection of antimicrobial agent will depend on local sensitivity patterns of uropathogens, whether or not the patient is hospitalized, and the relative costs of therapy.
In cases where local resistance patterns are not known, empirical therapy should include initial intravenous dose of a long-acting parenteral antimicrobial agent and starting with a broader-spectrum agent and then narrowing the therapy when laboratory results are available.Patients with signs of urosepsis should be given empiric antimicrobial therapy with coverage for extended spectrum β-lactamase (ESBL)-producing organisms. Oral therapy should always be considered in patients with mild to moderate symptoms.Parenteral therapy should be used in patients who are too ill to take oral antibiotics, then switch to oral therapy once tolerated. Patient should be treated for a total of 7-14 days.
For further information regarding the management of Urinary Tract Infection - Uncomplicated, please refer to Disease Algorithm for the Treatment Guideline.
