Alcohol-Related Liver Disease Differential Diagnosis

Differential Diagnosis

Alternative diagnoses for SLD include:

• Abetalipoproteinemia
• Acute fatty liver disease of pregnancy
• Drug-induced liver disease
• Hemolytic anemia, elevated liver enzymes, low platelet count (HELLP) syndrome
• HCV infection
• Inborn errors of metabolism (eg cholesterol ester storage disease, lecithin-cholesterol acyltransferase [LCAT] deficiency, Wolman disease)
• Lipodystorphy
• MASLD previously known as non-alcoholic fatty liver disease (NAFLD)
• Parenteral nutrition
• Reye syndrome
• Starvation
• Wilson disease

Alcoholic Hepatitis

Acute hepatitis may be due to:

• Acute fatty liver of pregnancy
• Acute viral hepatitis (hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E, herpes simplex virus [HSV], cytomegalovirus [CMV])
• Alpha-1 antitrypsin deficiency
• Autoimmune hepatitis
• Budd-Chiari syndrome
• Drug-induced liver injury or idiosyncratic drug reactions
• HELLP syndrome
• Ischemic hepatitis
• Non-alcoholic steatohepatitis
• Paracetamol toxicity
• Toxin-induced hepatitis (eg mushroom poisoning, carbon tetrachloride)
• Wilson disease

Chronic liver disease may be due to:

• HCV infection
• MASLD
• Metabolic disease

Cirrhosis

Cirrhosis may be caused by:

• Autoimmune hepatitis
• Chronic viral hepatitis
• Hemochromatosis
• Primary biliary cholangitis
• Primary sclerosing cholangitis