Chronic Myeloid Leukemia Initial Assessment

Clinical Presentation

The signs and symptoms of chronic myeloid leukemia include anemia, abdominal fullness, abdominal pain that may present with left upper quadrant pain and early satiety, bleeding episodes due to platelet dysfunction, fatigue, malaise, and weight loss. Other frequent findings are splenomegaly, raised platelet count, increased white blood cells (WBC) count, involvement of lymph nodes, skin and soft tissue as in the case of a patient in blast crisis.

Physical Examination

Part of the diagnosis of CML is a complete history and physical examination that includes the size of the spleen and liver.