Herpes Simplex Virus Infection Disease Summary

Last updated: 06 October 2025

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Overview

As stated in the Introduction section, herpes simplex virus (HSV) is a major health problem, causing a wide spectrum of diseases.  

HSV type 1 (HSV-1) affects as much as 3.8 billion individuals, while 520 million are infected with herpes simplex virus type 2 (HSV-2). Other details in its prevalence are discussed in the Epidemiology section.

The Pathophysiology section discusses how herpes simplex virus is transmitted and how it achieves latency. This section also states how reactivation brings about the appearance of vesicles and ulcers.

In the Classification section, the different types of herpes simplex virus infection are discussed.



Herpes Simplex Virus Infection_Disease SummaryHerpes Simplex Virus Infection_Disease Summary

History and Physical Examination

The Clinical Presentation section describes the signs and symptoms of herpes simplex virus disease.

Diagnosis

As mentioned in the Diagnosis and Diagnostic Criteria section, the diagnosis of herpes simplex virus is usually based on distinctive lesions. However, laboratory tests can be done to confirm diagnosis. The different lab tests that can be done to aid diagnosis are detailed in the Laboratory Tests and Ancillaries section.

Other diseases that should be ruled out in the diagnosis of herpes simplex virus infection are listed in the Differential Diagnosis section.

Management

The general principles in antiviral treatment in herpes simplex virus infection are discussed in the Principles of Therapy section.

The Pharmacological Therapy section provides details on symptomatic therapy, antiviral therapy, and management strategies for recurrent genital herpes.

The Nonpharmacological section includes patient/parent counseling and interventions such as cool compress, cool perineal baths, and sitz baths.

The Prevention section emphasizes the importance of educating patients on how to prevent transmission of herpes simplex virus.

The Monitoring section gives instructions on what to do in cases of treatment interruption.