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Osteoporosis Disease Summary

Last updated: 29 September 2025

Overview

Osteoporosis is a progressive, systemic skeletal disease characterized by decreased bone mass and microarchitectural deterioration of bone tissue, as stated in the Introduction section.

Osteoporosis imposes a significant worldwide healthcare burden. A detailed discussion about the prevalence of osteoporosis is in the Epidemiology section.

The developmental process of osteoporosis in affected individuals is in the Pathophysiology section.

The Risk Factors section enumerates the conditions associated with the development of osteoporosis.

Discussions on primary and secondary osteoporosis are in the Classification section.



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History and Physical Examination

The Clinical Presentation section describes the clinical features suggestive of osteoporosis.

The History and Physical Examination sections discuss the important information and assessments in patients suspected of osteoporosis.

Diagnosis

The Diagnosis or Diagnostic Criteria section features the features that should be present in the diagnosis of postmenopausal osteoporosis.

The Screening section discusses the tools to assess and screen patients with osteoporosis.

Discussions of tests that may be requested in patients suspected of osteoporosis are in the Laboratory Tests and Ancillaries section. 

The Imaging section discusses methods for bone mineral density (BMD) measurements and other radiologic studies for the evaluation of individuals with osteoporosis.

Other conditions that may cause fractures and decreased bone density are listed in the Differential Diagnosis section.

Management

Fracture risk categories in the evaluation of patients with osteoporosis are enumerated in the Evaluation section.

General therapy principles and management of osteoporosis are in the Principles of Therapy section.

The Pharmacological Therapy section explains therapy options for patients with osteoporosis, such as bisphosphonates, and hormonal therapy.

The Nonpharmacological section includes discussions on nutrition and lifestyle modifications in patients with osteoporosis.

Surgical options in the management of osteoporosis, such as vertebroplasty and kyphoplasty are discussed in the Surgery section.

The Monitoring section discusses treatment monitoring, follow-up diagnostic tests, and specialist referral in patients with osteoporosis.