Hypertrophic Cardiomyopathy Differential Diagnosis

Other conditions or phenotypic mimics that need to be ruled out, especially when concentric rather than asymmetric hypertrophy is present, are amyloidosis, Fabry disease, glycogen and lysosomal storage diseases, and mitochondrial diseases. Aortic and subaortic stenoses are occasionally mistaken for obstructive hypertrophic cardiomyopathy. The distinction should also be made between hypertrophic cardiomyopathy and conditions such as hypertensive heart disease, physiologic LV hypertrophy (athlete’s heart), dilated cardiomyopathy, or isolated basal septal hypertrophy in the elderly.