Migraine Headache Disease Summary

Last updated: 28 July 2025

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Overview

Migraine headache is a common episodic primary headache that is disabling with associated nausea and/or light and sound sensitivity, as stated in the Introduction section.

Based on the 2015 data from the World Health Organization (WHO), 50-75% of adults aged 18-65 years old in the world have had headaches, and ≥30% of them have reported having migraine headaches. A detailed discussion about the prevalence of migraine headaches is in the Epidemiology section.

The Pathophysiology section discusses the developmental process of migraine headache, which includes the activation of the trigeminovascular system and the pain of migraine being linked to the onset of neurogenic inflammation.

The risk factors and possible triggers of migraine headache are discussed in the Risk Factors section.



Migraine Headache_Disease SummaryMigraine Headache_Disease Summary

History and Physical Examination

The Clinical Presentation section describes the clinical features of migraine headache. The History and Physical Examination sections emphasize the importance of a thorough history and physical examination in the proper diagnosis of migraine headache.

Diagnosis

The Diagnosis or Diagnostic Criteria section features the different bases in classifying migraine headache as migraine with or without aura, chronic migraine, and episodic migraine.

The diseases that should be ruled out in the diagnosis of migraine headache are listed in the Differential Diagnosis section.

Management

Therapy decisions should be made based on the severity of headache. Severity categories and indications for prophylactic therapy are enumerated in the Evaluation section.

General therapy principles and management strategies for migraine headache dependent on whether such treatment is for an acute episode or for prophylaxis are discussed in the Principles of Therapy section.

The Pharmacological Therapy section discusses in detail the medication options for acute episodes and prophylactic treatment of migraine headache.

The Nonpharmacological section discusses the importance of patient education and lifestyle modification in the successful management of migraine headache.