Coexposure to bisphenols linked to metabolic diseases

A recent study has observed the association of bisphenol A (BPA) and its substitutes with specific metabolic diseases (MDs).

A total of 1,409 participants from the National Health and Nutrition Examination Survey (NHANES) were included in the analysis. The researchers explored the associations between bisphenol concentrations and comprehensive MDs, including their multimorbidity, using generalized linear regression, Bayesian kernel machine regression, and the weighted quantile sum (WQS) models.

The logistic regression model showed the independent association of BPA and bisphenol F with obesity, as well as the independent relationship of BP and bisphenol S (BPS) with multimorbidity.

In the Bayesian kernel machine regression analysis, the joint effects of the three chemicals correlated with hypertension and obesity, with BPS generating the highest posterior inclusion probability.

Finally, the WQS regression analysis revealed the significant associations of the WQS index with obesity and hypertension, with BPS being the highest contributor to both MDs.

“Our findings indicate that coexposure to bisphenols significantly increases the risk of obesity and hypertension,” the researchers said. 

BPA and its substitutes are known to be common environmental endocrine disruptors, according to the investigators, who then conducted this study to determine whether coexposure to BPA correlated with MDs, the related indicators, and their multimorbidity.