Dietary manganese helps lower uric acid levels in Chinese adults

Eating foods high in manganese appears to confer protection against hyperuricaemia in Chinese adults, as shown in a study.

Researchers used data from the China Health and Nutrition Survey 1997–2009 and included 6,886 adult participants. The trajectories of dietary manganese intake were evaluated by sex and used to group the participants. Cox proportional hazard models were used to analyse the risk of hyperuricaemia in relation to dietary manganese intake.

In men, moderate to high dietary manganese intake trajectory was associated with a 39-percent reduction in the risk of hyperuricaemia compared with low stable trajectory (hazard ratio [HR], 0.61, 95 percent confidence interval [CI], 0.38–0.98). Of note, the observed association was partially regulated by the following factors: total cholesterol, high-density lipoprotein cholesterol (HDL-C), apolipoprotein B, and triglycerides.

Results in women, on the other hand, showed that high stable dietary manganese intake trajectory was associated with 24-percent reduction in the risk of hyperuricaemia when compared with low stable trajectory (HR, 0.76, 95 percent CI, 0.60–0.95). This association was partially regulated by total cholesterol, HDL-C, apolipoprotein B, and apolipoprotein A.

The study was said to be the first to investigate the relationship between the dynamic change of dietary manganese intake and hyperuricaemia risk.