TTSS system closes gastrointestinal defects after endoscopy

The recently approved through-the-scope suturing (TTSS) system demonstrates safety and efficacy in the closure of mucosal defects following therapeutic endoscopic interventions, reports a recent study.

This meta-analysis included 12 eligible studies involving a total of 512 patients (mean age 61.5 percent, 54.6 percent female).

TTSS had a technical success rate of 96.0 percent (95 percent confidence interval [CI], 94.3–97.7), while its primary and overall clinical success rates were 74.8 percent (95 percent CI, 65.5–84.1) and 95.4 percent (95 percent CI, 92.6–98.2), respectively.

One patient death was reported, but it was deemed unrelated to the intervention.

“Further cost-effective studies should be performed comparing with endoclips for use in clinical settings,” the researchers said. 

In this study, a group of researchers used the databases of Embase, Medline, Cochrane Central Register of Controlled Trials, and Web of Science Core Collection. The reasons cited by endoscopists for the use of TTSS were as follows: endoscopic mucosal resection, endoscopic submucosal dissection, peroral endoscopic myotomy, perforation, fistula closure, and/or stent fixation.

Outcomes measured included technical success, primary clinical success (closure of defect without additional intervention), and overall clinical success (closure of defect with/without additional intervention). Event rates, expressed as proportions with a 95 percent CI, were measured using a random effects model with the DerSimonian Laird approach.