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Novel GLP-1/FGF21 dual agonist shows promise in treatment of MASLD with T2DM

26 May 2025

The glucagon-like peptide-1 (GLP-1) and fibroblast growth factor 21 (FGF21) dual agonist HEC88473 demonstrates an acceptable safety profile and potential efficacy in the management of patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes mellitus (T2DM).

Novel GLP-1/FGF21 dual agonist shows promise in treatment of MASLD with T2DM

26 May 2025

Linerixibat quells cholestatic itch in PBC, enabling better sleep

23 May 2025 bởi

The ileal bile acid transporter inhibitor linerixibat provides rapid and substantial relief from cholestatic pruritus, in turn reducing associated sleep disturbances, in patients with primary biliary cholangitis (PBC), as shown in the global, phase III GLISTEN trial.

Linerixibat quells cholestatic itch in PBC, enabling better sleep

23 May 2025

Resmetirom reduces liver stiffness, portal hypertension in MASH cirrhosis

19 May 2025 bởi

Treatment with resmetirom improves liver stiffness, fibrosis biomarkers, and risk scores for clinically significant portal hypertension (CSPH) in patients with metabolic dysfunction-associated steatohepatitis (MASH) cirrhosis at 2 years, according to a study.

Resmetirom reduces liver stiffness, portal hypertension in MASH cirrhosis

19 May 2025

Does long-term albumin therapy prolong survival in cirrhotic patients?

18 May 2025 bởi

Long-term human albumin (LTA) therapy among cirrhotic patients with existing or prior ascites and acute decompensation results in improved transplant-free survival (TFS), mortality, and disease-related complications, according to the results of the PRECIOSA trial.

Does long-term albumin therapy prolong survival in cirrhotic patients?

18 May 2025

ACE-I/ARB use helps avert death in cirrhosis patients

13 May 2025

Exposure to angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARB) may prevent mortality among patients with cirrhosis, a study has shown.

ACE-I/ARB use helps avert death in cirrhosis patients

13 May 2025

TAF prophylaxis prevents mother-to-child transmission of HBV

13 May 2025

Treatment with tenofovir alafenamide (TAF) is generally safe and effective for the prevention of hepatitis B virus (HBV) mother-to-child transmission (MTCT), reports a study, noting that the expected 8-week prenatal duration is feasible.

TAF prophylaxis prevents mother-to-child transmission of HBV

13 May 2025

Another win for semaglutide: Improved outcomes in MASH with fibrosis

12 May 2025 bởi

Semaglutide may also confer hepatoprotective benefits, with interim efficacy data from the ongoing phase III ESSENCE study showing that the glucagon-like peptide-1 (GLP-1) receptor agonist helps dial down disease activity in patients with metabolic dysfunction–associated steatohepatitis (MASH) and moderate-to-severe fibrosis.

Another win for semaglutide: Improved outcomes in MASH with fibrosis

12 May 2025

Original-New-Drug-Application-Approvals-by-US-FDA--1-15-April-2025

02 May 2025

New drug applications approved by US FDA as of 1-15 April 2025 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original-New-Drug-Application-Approvals-by-US-FDA--1-15-April-2025

02 May 2025

SOF/VEL combo improves well-being of children with CHC

27 Apr 2025 bởi

In children with chronic hepatitis C (CHC), effective treatment with sofosbuvir/velpatasvir (SOF/VEL) results in improvements in certain areas of their well-being at 1 year. This suggests some patient-reported outcomes (PRO) benefits of direct-acting antiviral (DAA) therapy. However, the parents’ proxy reports show a decrease in the patients’ school functioning.

SOF/VEL combo improves well-being of children with CHC

27 Apr 2025

BPaL regimen tied to liver injury

10 Apr 2025

The overall risk of drug-induced liver injury (DILI) with the pretomanid, bedaquiline and linezolid (BPaL) regimen is lower compared with the isoniazid, rifampin, pyrazinamide and ethambutol (HRZE) regimen, a study has shown. However, the association between BPal and DILI remains significant, suggesting the need for careful monitoring during treatment.

BPaL regimen tied to liver injury

10 Apr 2025

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Novel GLP-1/FGF21 dual agonist shows promise in treatment of MASLD with T2DM

Novel GLP-1/FGF21 dual agonist shows promise in treatment of MASLD with T2DM

Linerixibat quells cholestatic itch in PBC, enabling better sleep

Linerixibat quells cholestatic itch in PBC, enabling better sleep

Resmetirom reduces liver stiffness, portal hypertension in MASH cirrhosis

Resmetirom reduces liver stiffness, portal hypertension in MASH cirrhosis

Does long-term albumin therapy prolong survival in cirrhotic patients?

Does long-term albumin therapy prolong survival in cirrhotic patients?

ACE-I/ARB use helps avert death in cirrhosis patients

ACE-I/ARB use helps avert death in cirrhosis patients

TAF prophylaxis prevents mother-to-child transmission of HBV

TAF prophylaxis prevents mother-to-child transmission of HBV

Another win for semaglutide: Improved outcomes in MASH with fibrosis

Another win for semaglutide: Improved outcomes in MASH with fibrosis

Original-New-Drug-Application-Approvals-by-US-FDA--1-15-April-2025

Original-New-Drug-Application-Approvals-by-US-FDA--1-15-April-2025

SOF/VEL combo improves well-being of children with CHC

SOF/VEL combo improves well-being of children with CHC

BPaL regimen tied to liver injury

BPaL regimen tied to liver injury