Acne Vulgaris Disease Summary

Last updated: 25 May 2026

Overview

Acne vulgaris is chronic inflammatory dermatosis which is notable for open and/or closed comedones (blackheads and whiteheads) and inflammatory lesions including papules, pustules, nodules, and cysts as mentioned in the Introduction section.  

Acne has an overall prevalence of 20.5%, with the highest rates noted in individuals 16 to 24 years of age. The Epidemiology section discusses prevalence of acne regionally.  

Development of acne involves different factors, and the Pathophysiology and Risk Factors sections discuss further about these factors.  

Types of acne are based on lesions that occur and sites of distribution. These are enumerated and described in the Classification section. 

History and Physical Examination

The History section mentions that finding out on the information of past treatments can be necessary to elicit in the patient as well as the other contributing factors that are enumerated in this section.

During the Physical Examination one should inspect the lesions seen and site of distribution to classify the type of acne the patient has.

Diagnosis

The Evaluation section enumerates the different scoring methods used in grading acne lesions. Currently, there is no recommended universal grading or classifying system for acne. This section also discusses the severity classification by Lehman.

The Differential Diagnosis section enumerates the different skin diseases that can be considered in diagnosing if comedones are not present. 

Management

The Principles of Therapy section discusses the goals of therapy and phases of pharmacological therapy for acne.

Topical agents like retinoids, Azelaic acid, Benzoyl peroxide, antibiotics, salicylic acid and Clascoterone that are used in the management of acne are discussed in detail in the Pharmacological Therapy section. In this section considerations when choosing topical agent are also enumerated. Oral agents (eg antibiotics, Isotretinoin, corticosteroids), intralesional corticosteroids, and adjunctive therapies are also discussed in this section.  

In the Nonpharmacological section patient education, diet, and skin care recommendations are featured and discussed in detail. Energy-based devices descriptions are also in this section. 

Frequently Asked Questions

How are acne vulgaris lesions classified?
Acne lesions are classified as comedonal, papulopustular, nodular or nodulocystic. Comedonal acne is non-inflammatory and consists of closed comedones or whiteheads and open comedones or blackheads. Papulopustular acne is inflammatory and includes papules and pustules. Nodular and nodulocystic acne represent severe inflammatory acne with nodules, cysts and deep pustules. Read more
How should acne severity be evaluated?
Assessment should consider the number and type of lesions, disease severity, affected anatomical sites and propensity for scarring. Although no universal acne grading system is recommended, lesion counting and grading systems may be used. The most severe lesions present should receive particular attention because appropriate treatment of these lesions generally also addresses less severe lesions. Read more
How is acne treatment selected by severity?
Treatment is based on acne lesion type and severity, previous treatment, childbearing potential and contributing factors. Topical therapy is the principal treatment for mild acne, while moderate to severe acne generally requires topical and systemic therapies. Treatment aims to clear lesions, prevent physical and psychological complications, maintain remission and reduce relapse. Read more
When are topical retinoids recommended for acne?
Topical retinoids such as Adapalene, Tazarotene, Tretinoin and Trifarotene are effective first-line treatments for comedonal and inflammatory acne. They reduce microcomedone formation, limit development of new lesions and promote follicular epithelial desquamation. Retinoids may be used alone for mild non-inflammatory comedonal acne or combined with other agents for inflammatory or moderate to severe acne. Read more
How should antibiotics be used for acne?
Topical antibiotics are useful for mild to moderate inflammatory acne but should be combined with Benzoyl peroxide or a topical retinoid to reduce antimicrobial resistance. Oral antibiotics are generally used for moderate to severe inflammatory acne that does not respond to topical combinations or has a high risk of scarring. Antibiotics should not be used as monotherapy for moderate to severe acne. Read more