Acute Coronary Syndromes without Persistent ST-Segment Elevation Differential Diagnosis

Last updated: 22 May 2026

Differential Diagnosis

In patients presenting with suspected ACS, clinicians should also consider other cardiac and non-cardiac causes of chest pain including:

  • Acute cholecystitis
  • Acute pericarditis
  • Aortic dissection
  • Aortic stenosis
  • Asthma
  • Gastroesophageal reflux disease
  • Herpes zoster
  • Myocarditis
  • Neuromusculoskeletal causes (eg costochondritis, cervical radiculopathy)
  • Peptic ulcer disease
  • Pneumonia or pleurisy
  • Pulmonary embolism