Constipation in Adults - Chronic, Functional Disease Summary

Last updated: 23 January 2026

Overview

Constipation is an unsatisfactory defecation distinguished by difficult stool passage, infrequent stools (<3 bowel movements/week), or both, as stated in the Introduction section.

The prevalence of constipation ranges from 6.6-11.7% according to a survey of individuals aged 18 and above across 33 countries. A detailed discussion about the prevalence of constipation is in the Epidemiology section.

The most recognized causes of constipation include sensorimotor disturbances in the colon and pelvic floor dysfunction. Further discussions on secondary causes of constipation are in the Etiology section.

The Pathophysiology section states that the symptoms of chronic constipation may be due to dysfunction of intestinal motility, visceral sensitivity (eg increased rectal sensory threshold or loss of urge to defecate), anorectal musculature, or the enteric nervous system.  

The Risk Factors section lists factors that contribute to the development of constipation in adults.



Constipation in Adults_Disease SummaryConstipation in Adults_Disease Summary

History and Physical Examination

The History section states the importance of inquiring regarding current bowel regimen, frequency, and pattern in the diagnosis of constipation. Other information that should be asked is discussed in this section.

The Physical Examination section emphasizes the importance of evaluating the abdomen and other organ systems to eliminate potential causes of chronic constipation. Discussions on rectal exams and digital rectal exams of the rectum are also in this section.

Diagnosis

The Diagnosis or Diagnostic Criteria section explains functional constipation and the Rome IV diagnostic criteria.

Alarm signs and symptoms to watch out for in the diagnosis of constipation are listed in the Screening section.  

The importance of laboratory tests such as a complete blood count and other specific metabolic tests such as thyroid and renal function tests in the evaluation of chronic constipation is in the Laboratory Tests and Ancillaries section.  

The Imaging section emphasizes the need for imaging or colonoscopy in the diagnosis of constipation in patients who present with alarm symptoms or are ≥50 years of age. Specialized physiologic tests in the evaluation of chronic constipation are also discussed in this section.

Secondary causes of constipation that should be ruled out in the diagnosis of constipation are listed in the Differential Diagnosis section.

Management

General therapy principles and management of constipation are in the Principles of Therapy section.

The Pharmacological Therapy section discusses in detail the symptomatic therapy, such as laxatives, enemas, and other agents prescribed in the management of constipation.

The Nonpharmacological section includes things to educate the patient and the importance of dietary modification in the management of constipation. 

Indications for surgical referral for the treatment of constipation are in the Surgery section.

The Monitoring section identifies patients who do not respond to conventional therapy and treatment options for those patients who have treatment failure for constipation.