Multidisciplinary care may improve HIV PEP adherence in sexual assault victims

Initiation of postexposure prophylaxis for HIV and completion rates in paediatric sexual assault victims can be improved by implementing a structured care system that involves multidisciplinary collaboration, pioneered by paediatric infectious diseases, suggests a Turkey study.

One hundred nineteen patients met the eligibility criteria for this study. Of these, 97 percent initiated PEP, and 70 percent completed the regimen. Compliance did not significantly differ by age or sex, whereas follow-up adherence showed a progressive decline, from 55 percent at the first month to 30 percent by the sixth month.

In terms of safety, one patient experienced nausea and vomiting, which indicated a low incidence of side effects. Furthermore, none of the children seroconverted to HIV.

“Single-pill PEP regimens may enhance adherence,” the authors said. “However, the decline in follow-up rates underscores the need for improved follow-up mechanisms and future interventions.”

This retrospective analysis was conducted on paediatric patients aged 1 month to 18 years, treated between September 2017 and September 2022. The authors collected data on demographics, PEP initiation and completion, follow-up rates, and serologic testing for HIV. They also analysed PEP compliance, follow-up adherence, and outcomes.

“PEP is critical in preventing HIV acquisition after risky exposures, particularly in paediatric sexual assault victims,” the authors said. “Despite its importance, adherence and follow-up remain significant challenges.”