News & Updates

Investigational triple–hormone-receptor agonist reduces fat mass in people with T2D

Treatment with retatrutide—an agonist of the glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and glucagon receptors—appears to result in greater total body fat mass reduction in individuals with type 2 diabetes (T2D) and high BMI when compared with placebo and dulaglutide, according to a substudy of a phase II trial.

Investigational triple–hormone-receptor agonist reduces fat mass in people with T2D

4 hours ago

Pembrolizumab + CCRT ups survival in high-risk LACC

8 hours ago by

Treatment with the combination of pembrolizumab and concurrent chemoradiotherapy (CCRT), followed by pembrolizumab maintenance, led to a sustained, long-term survival benefit in patients with high-risk, locally advanced cervical cancer (LACC) compared with CCRT alone, according to the final analysis of the phase III ENGOT-cx11/GOG-3047/KEYNOTE-A18 trial presented at ASCO 2025.

Pembrolizumab + CCRT ups survival in high-risk LACC

8 hours ago

SGLT-2 inhibitors may provide liver-related benefits to patients with cirrhosis

20 hours ago by

The use of a sodium-glucose cotransporter 2 (SGLT-2) inhibitor helps lower the incidence of serious liver events among patients with cirrhosis who are receiving diuretic therapy, according to a study.

SGLT-2 inhibitors may provide liver-related benefits to patients with cirrhosis

20 hours ago

Does testosterone level predict metastasis-free survival in nmCRPC?

21 hours ago

Maintenance serum testosterone levels ≥20 ng/dL do not appear predictive of worse metastasis-free survival (MFS) among men with testosterone <50 ng/dL on first-line therapy of nonmetastatic castration-resistant prostate cancer (nmCRPC) using novel hormonal agents, according to a study.

Does testosterone level predict metastasis-free survival in nmCRPC?

21 hours ago

Malays most referred patients to nephrology care in SG

22 hours ago by

A Singapore study has found that patients referred for kidney disease are predominantly Malays, who tend to have higher metabolic disease burden, miss their appointments, and be referred at lower estimated glomerular filtration rate (eGFR).

Malays most referred patients to nephrology care in SG

22 hours ago

Defibrillation testing may be omitted in most recipients of S-ICD

23 hours ago

The majority of subcutaneous implantable cardioverter defibrillator (S-ICD) recipients may safely forgo defibrillation testing (DT) during implantation, suggests a study. However, selective DT may be considered in those at higher risk.

Defibrillation testing may be omitted in most recipients of S-ICD

23 hours ago

Oral mitapivat beneficial in the treatment of non-transfusion-dependent thalassaemia

a day ago

Mitapivat, an oral activator of pyruvate kinase, appears to increase haemoglobin concentration and improve fatigue in adults with non-transfusion-dependent (NTD) α-thalassaemia or NTD β-thalassaemia, according to the double-blind phase III ENERGIZE study.

Oral mitapivat beneficial in the treatment of non-transfusion-dependent thalassaemia

a day ago

Structured exercise after adjuvant chemotherapy for colon cancer extend overall survival

a day ago by

A structured exercise programme offered alongside health education materials may prolong overall survival (OS) in patients with resected colon cancer who have completed adjuvant chemotherapy, according to the final results of the phase III CHALLENGE trial presented at ASCO 2025.

Structured exercise after adjuvant chemotherapy for colon cancer extend overall survival

a day ago

Pramipexole augmentation helps in treatment-resistant depression, but side effects noted

a day ago by

Augmenting antidepressants with pramipexole substantially improves treatment-resistant depression, although it comes with some adverse effects, according to the results of a randomized controlled trial.

Pramipexole augmentation helps in treatment-resistant depression, but side effects noted

a day ago

Fibromyalgia linked to lower sexual desire in women

a day ago

Sexual desire is reduced in women with fibromyalgia, driven primarily by age, time since diagnosis, and depressive symptoms, according to a study.

Fibromyalgia linked to lower sexual desire in women

a day ago

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Investigational triple–hormone-receptor agonist reduces fat mass in people with T2D

Investigational triple–hormone-receptor agonist reduces fat mass in people with T2D

Pembrolizumab + CCRT ups survival in high-risk LACC

Pembrolizumab + CCRT ups survival in high-risk LACC

SGLT-2 inhibitors may provide liver-related benefits to patients with cirrhosis

SGLT-2 inhibitors may provide liver-related benefits to patients with cirrhosis

Does testosterone level predict metastasis-free survival in nmCRPC?

Does testosterone level predict metastasis-free survival in nmCRPC?

Malays most referred patients to nephrology care in SG

Malays most referred patients to nephrology care in SG

Defibrillation testing may be omitted in most recipients of S-ICD

Defibrillation testing may be omitted in most recipients of S-ICD

Oral mitapivat beneficial in the treatment of non-transfusion-dependent thalassaemia

Oral mitapivat beneficial in the treatment of non-transfusion-dependent thalassaemia

Structured exercise after adjuvant chemotherapy for colon cancer extend overall survival

Structured exercise after adjuvant chemotherapy for colon cancer extend overall survival

Pramipexole augmentation helps in treatment-resistant depression, but side effects noted

Pramipexole augmentation helps in treatment-resistant depression, but side effects noted

Fibromyalgia linked to lower sexual desire in women

Fibromyalgia linked to lower sexual desire in women