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Dapagliflozin safe, effective in sickle cell nephropathy

The use of dapagliflozin results in a significant improvement in albuminuria and is well tolerated among patients with sickle cell disease (SCD), reports a study presented at ASH 2025. However, a few of them have experienced a complication of urinary tract infections (UTIs).

Dapagliflozin safe, effective in sickle cell nephropathy

11 hours ago

Does aspirin use improve outcomes in APS patients with arterial thrombosis?

12 hours ago by

The addition of low-dose aspirin to warfarin appears to increase the risk of major bleeding in patients with antiphospholipid syndrome (APS) but falls short in reducing all-cause mortality, according to a study presented at ASH 2025. Likewise, the rates of ischemic stroke and acute myocardial infarction are also higher among aspirin users.

Does aspirin use improve outcomes in APS patients with arterial thrombosis?

12 hours ago

Topiramate tied to weight loss vs other antiseizure drugs

13 hours ago

Among commonly used antiseizure medications (ASMs), topiramate appears to result in weight loss at 6 and 12 months under either initiation and subsequent adherence or initiation-only effects, reports a study. Other ASMs seem to contribute to greater weight change.

Topiramate tied to weight loss vs other antiseizure drugs

13 hours ago

Ivonescimab trumps tislelizumab for squamous NSCLC in HARMONi-6

14 hours ago by

In the phase III HARMONi-6 trial, ivonescimab plus chemotherapy significantly improved progression-free survival (PFS) compared with tislelizumab plus chemo as first-line treatment for individuals with advanced squamous non-small cell lung cancer (NSCLC).

Ivonescimab trumps tislelizumab for squamous NSCLC in HARMONi-6

14 hours ago

4-week ustekinumab dosing revs up response in Crohn’s disease

a day ago by

For Crohn’s disease (CD) patients with suboptimal response to ustekinumab, doubling the dosing frequency from every 8 weeks to every 4 weeks elicited meaningful improvements in objective and patient-reported outcomes, as shown in a small retrospective study.

4-week ustekinumab dosing revs up response in Crohn’s disease

a day ago

Adequate sleep helps prevent obesity in boys

a day ago

A recent study suggests interventions for children to help them achieve their recommended sleep duration for weekdays and weekends and thus reduce abdominal and total adiposity, particularly in boys.

Adequate sleep helps prevent obesity in boys

a day ago

Follow-up care a must for late effects in childhood cancer survivors

a day ago by

Timely screening is needed to enhance early detection of metabolic health, bone health, and hearing impairment among childhood cancer survivors treated in Singapore, suggests a recent study. Adoption of an exposure-based approach to proactively screen for late effects can reduce biopsychosocial impacts.

Follow-up care a must for late effects in childhood cancer survivors

a day ago

Maternal prepregnancy BMI predicts cardiometabolic outcomes in offspring

a day ago

High maternal BMI prior to pregnancy appears to contribute to a BMI increase in their offspring during childhood, reveals a study. Moreover, preterm children are more likely to develop hypertension than their term counterparts.

Maternal prepregnancy BMI predicts cardiometabolic outcomes in offspring

a day ago

Real-world study supports high-dose IV iron for IBD-associated anaemia

a day ago by

Real-world evidence shows the efficacy and safety of high-dose intravenous (IV) iron for the treatment of anaemia in individuals with inflammatory bowel disease (IBD), irrespective of inflammatory activity.

Real-world study supports high-dose IV iron for IBD-associated anaemia

a day ago

Yoga of little benefit in IBS

a day ago

For patients with irritable bowel syndrome (IBS), practicing yoga does not help improve symptoms, anxiety, depression, and quality of life, according to a systematic review and meta-analysis.

Yoga of little benefit in IBS

a day ago

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Dapagliflozin safe, effective in sickle cell nephropathy

Dapagliflozin safe, effective in sickle cell nephropathy

Does aspirin use improve outcomes in APS patients with arterial thrombosis?

Does aspirin use improve outcomes in APS patients with arterial thrombosis?

Topiramate tied to weight loss vs other antiseizure drugs

Topiramate tied to weight loss vs other antiseizure drugs

Ivonescimab trumps tislelizumab for squamous NSCLC in HARMONi-6

Ivonescimab trumps tislelizumab for squamous NSCLC in HARMONi-6

4-week ustekinumab dosing revs up response in Crohn’s disease

4-week ustekinumab dosing revs up response in Crohn’s disease

Adequate sleep helps prevent obesity in boys

Adequate sleep helps prevent obesity in boys

Follow-up care a must for late effects in childhood cancer survivors

Follow-up care a must for late effects in childhood cancer survivors

Maternal prepregnancy BMI predicts cardiometabolic outcomes in offspring

Maternal prepregnancy BMI predicts cardiometabolic outcomes in offspring

Real-world study supports high-dose IV iron for IBD-associated anaemia

Real-world study supports high-dose IV iron for IBD-associated anaemia

Yoga of little benefit in IBS

Yoga of little benefit in IBS