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Bile acid accumulation predicts liver injury after portoenterostomy

The accumulation of altered serum bile acids appears to increase the risk of liver disease progression and result in poorer transplant-free survival following Kasai portoenterostomy (KPE) for biliary atresia (BA), a study has shown.

Bile acid accumulation predicts liver injury after portoenterostomy

8 hours ago

First-line antiseizure medications equally effective in routine paediatric care

14 hours ago

In the first-line treatment of newly diagnosed childhood epilepsy, antiseizure medications (ASMs) such as oxcarbazepine, valproate, levetiracetam, topiramate, and lamotrigine perform similarly, with no notable difference in outcomes, according to a retrospective cohort study.

First-line antiseizure medications equally effective in routine paediatric care

14 hours ago

Navepegritide tied to increased growth velocity in children with ACH

18 hours ago by

Once-weekly treatment with navepegritide was associated with significantly improved annualized growth velocity (AGV) in children with achondroplasia (ACH) compared with placebo, according to results from the pivotal ApproaCH trial presented at ENDO 2025.

Navepegritide tied to increased growth velocity in children with ACH

18 hours ago

Several factors tied to treatment failure in children starting first-line ART

a day ago by

In children living with HIV initiating antiretroviral therapy (ART), factors such as the ART regimen, age, BMI, and baseline CD4 count, among others, can predict treatment failure, according to a study.

Several factors tied to treatment failure in children starting first-line ART

a day ago

Third-line secukinumab tied to reduced survival in axSpA, axPsA

a day ago by

A real-word study in Argentina has found poor access to secukinumab treatment among patients with public health insurance than those using the social security system or private health coverage. Furthermore, use of secukinumab as third-line therapy or higher is associated with less survival.

Third-line secukinumab tied to reduced survival in axSpA, axPsA

a day ago

$Vedolizumab–tofacitinib combo induces response in refractory UC$

Vedolizumab–tofacitinib combo induces response in refractory UC

a day ago

Patients with ulcerative colitis (UC) refractory to anti-TNF and second-line therapies appear to benefit from combination therapy with vedolizumab plus tofacitinib, with many of them achieving clinical remission, as shown in a study.

Vedolizumab–tofacitinib combo induces response in refractory UC

a day ago

Lung nodule surveillance programme helps detect early-stage lung cancer

a day ago by

A lung nodule surveillance programme at Queen Mary Hospital (QMH) facilitates diagnosis of early-stage lung cancer. Data from the programme’s first year of implementation showed a higher proportion of early-stage lung cancer diagnoses compared with the Hong Kong Cancer Registry’s (HKCR) annual report.

Lung nodule surveillance programme helps detect early-stage lung cancer

a day ago

Novel once-weekly oral ART regimen scores high for viral suppression maintenance

21 Aug 2025 by

A once-weekly oral antiretroviral therapy (ART) regimen combining the nucleoside reverse transcriptase translocation inhibitor (NRTTI) islatravir with the non-nucleoside reverse transcriptase inhibitor (NNRTI) ulonivirine helps maintain viral suppression in adults living with HIV-1, according to a phase IIb study.

Novel once-weekly oral ART regimen scores high for viral suppression maintenance

21 Aug 2025

Inflammatory diet ups risk of constipation

21 Aug 2025 by

Individuals with a high inflammatory diet are at increased risk of constipation, suggests a study. Moreover, gender and physical activity may influence such relationship.

Inflammatory diet ups risk of constipation

21 Aug 2025

Real-world data support tirzepatide + hormone therapy for weight loss in postmenopausal women

21 Aug 2025 by

In postmenopausal women with overweight or obesity, the use of tirzepatide alongside menopause hormone therapy appears to yield better weight loss outcomes than treating with tirzepatide alone, findings from a real-world analysis have shown.

Real-world data support tirzepatide + hormone therapy for weight loss in postmenopausal women

21 Aug 2025

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Bile acid accumulation predicts liver injury after portoenterostomy

Bile acid accumulation predicts liver injury after portoenterostomy

First-line antiseizure medications equally effective in routine paediatric care

First-line antiseizure medications equally effective in routine paediatric care

Navepegritide tied to increased growth velocity in children with ACH

Navepegritide tied to increased growth velocity in children with ACH

Several factors tied to treatment failure in children starting first-line ART

Several factors tied to treatment failure in children starting first-line ART

Third-line secukinumab tied to reduced survival in axSpA, axPsA

Third-line secukinumab tied to reduced survival in axSpA, axPsA

Vedolizumab–tofacitinib combo induces response in refractory UC

Vedolizumab–tofacitinib combo induces response in refractory UC

Lung nodule surveillance programme helps detect early-stage lung cancer

Lung nodule surveillance programme helps detect early-stage lung cancer

Novel once-weekly oral ART regimen scores high for viral suppression maintenance

Novel once-weekly oral ART regimen scores high for viral suppression maintenance

Inflammatory diet ups risk of constipation

Inflammatory diet ups risk of constipation

Real-world data support tirzepatide + hormone therapy for weight loss in postmenopausal women

Real-world data support tirzepatide + hormone therapy for weight loss in postmenopausal women