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CNS-penetrant oral RIPK1 inhibitor flops for ALS

The selective, oral, central nervous system-penetrant reversible RIPK1 inhibitor SAR443820 appears to have limited clinical benefit in amyotrophic lateral sclerosis (ALS) and is even associated with greater hepatic enzyme increase, according to the phase II HIMALAYA trial.

CNS-penetrant oral RIPK1 inhibitor flops for ALS

1 hour ago

Aficamten shows promise for nonobstructive HCM

5 hours ago by

Treatment with aficamten significantly improves patient-reported health status and exercise capacity in patients with symptomatic nonobstructive hypertrophic cardiomyopathy (nHCM), according to the ACACIA-HCM trial presented at ESC 2026.

Aficamten shows promise for nonobstructive HCM

5 hours ago

PMOS’ cross-generation reproductive & cardiometabolic impacts warrant early monitoring of offspring

7 hours ago by

Offsprings of women with polycystic ovarian syndrome (PCOS) – renamed as polyendocrine metabolic ovarian syndrome (PMOS) since May 2026 – exhibit cardiometabolic and reproductive alterations in young adulthood, researchers from the Chinese University of Hong Kong (CUHK) have reported.

PMOS’ cross-generation reproductive & cardiometabolic impacts warrant early monitoring of offspring

7 hours ago

No link between tirzepatide and atrial fibrillation, arrhythmia

13 hours ago

Treatment with tirzepatide does not appear to be associated with atrial fibrillation or atrial arrhythmia in individuals with overweight or obesity, according to a meta-analysis.

No link between tirzepatide and atrial fibrillation, arrhythmia

13 hours ago

Two-drug noninferior to three-drug ART as initial HIV treatment

17 hours ago by

In individuals with untreated HIV-1 infection, the two-drug dolutegravir/lamivudine (DTG/3TC) antiretroviral therapy (ART) regimen has similar efficacy as the three-drug bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen, according to the phase IIIb VOGUE study.

Two-drug noninferior to three-drug ART as initial HIV treatment

17 hours ago

KD seasonality shifts from winter to summer after COVID-19 pandemic

18 hours ago

A 10-year study in Japan has found that the seasonality of Kawasaki Disease (KD) has not returned to the usual winter-dominant pattern even after lifting the COVID-19 infection mitigation measures.

KD seasonality shifts from winter to summer after COVID-19 pandemic

18 hours ago

Metabolic syndrome raises risk of excessive scarring

19 hours ago by

A significant association exists between metabolic syndrome (MetS) and an increased risk of excessive scarring, highlighting the potential of MetS management in preventing scarring, according to a study.

Metabolic syndrome raises risk of excessive scarring

19 hours ago

TSH testing patterns similar between GLP-1 RAs, SGLT-2 inhibitors in diabetes patients on levothyroxine

20 hours ago

Patterns of thyroid-stimulating hormone (TSH) test show no substantial difference between type 2 diabetes patients treated with GLP-1 RAs and those who received SGLT-2 inhibitors, a study has found.

TSH testing patterns similar between GLP-1 RAs, SGLT-2 inhibitors in diabetes patients on levothyroxine

20 hours ago

SUNRISE supports tezepelumab in severe OCS-dependent asthma

21 hours ago by

In the phase III SUNRISE trial, tezepelumab significantly reduces daily maintenance oral corticosteroid (OCS) dose while maintaining asthma control in adults with severe OCS-dependent asthma, despite early study termination and the smaller-than-planned sample size.

SUNRISE supports tezepelumab in severe OCS-dependent asthma

21 hours ago

SBRT shows slightly lower late GI and GU toxicities than conventional RT in prostate cancer

22 hours ago by

Stereotactic body radiotherapy (SBRT) provides comparable 5-year biochemical progression-free survival (PFS) and is associated with slightly lower rates of gastrointestinal (GI) and genitourinary (GU) toxicities compared with conventional radiotherapy (RT) in Chinese patients with low- to intermediate-risk prostate cancer, according to a real-world study in Hong Kong.

SBRT shows slightly lower late GI and GU toxicities than conventional RT in prostate cancer

22 hours ago

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CNS-penetrant oral RIPK1 inhibitor flops for ALS

CNS-penetrant oral RIPK1 inhibitor flops for ALS

Aficamten shows promise for nonobstructive HCM

Aficamten shows promise for nonobstructive HCM

PMOS’ cross-generation reproductive & cardiometabolic impacts warrant early monitoring of offspring

PMOS’ cross-generation reproductive & cardiometabolic impacts warrant early monitoring of offspring

No link between tirzepatide and atrial fibrillation, arrhythmia

No link between tirzepatide and atrial fibrillation, arrhythmia

Two-drug noninferior to three-drug ART as initial HIV treatment

Two-drug noninferior to three-drug ART as initial HIV treatment

KD seasonality shifts from winter to summer after COVID-19 pandemic

KD seasonality shifts from winter to summer after COVID-19 pandemic

Metabolic syndrome raises risk of excessive scarring

Metabolic syndrome raises risk of excessive scarring

TSH testing patterns similar between GLP-1 RAs, SGLT-2 inhibitors in diabetes patients on levothyroxine

TSH testing patterns similar between GLP-1 RAs, SGLT-2 inhibitors in diabetes patients on levothyroxine

SUNRISE supports tezepelumab in severe OCS-dependent asthma

SUNRISE supports tezepelumab in severe OCS-dependent asthma

SBRT shows slightly lower late GI and GU toxicities than conventional RT in prostate cancer

SBRT shows slightly lower late GI and GU toxicities than conventional RT in prostate cancer