News & Updates

In patients with psoriatic arthritis (PsA) inadequately controlled by a tumour necrosis factor inhibitor (TNFi), combination treatment with guselkumab plus golimumab appears to yield clinically meaningful benefits only in those with elevated C-reactive protein levels, as shown in a study.

Alcohol consumption contributes to increased mortality and major adverse cardiovascular events (MACE) among US veterans, with a J-shaped association indicating reduced risk at moderate consumption levels compared with abstinence of heavier drinking, suggests a study.

Children born to mothers with autoimmune diseases during pregnancy are at increased risk of type 1 diabetes (T1D), according to a study.

Accelerated biological ageing is associated with increased gout prevalence and incidence and all-cause mortality, according to a study.

Cutting thickened or retracted secondary chordae of the anterior mitral leaflet related to septal myectomy demonstrates positive long-term clinical and haemodynamic results in patients with hypertrophic cardiomyopathy (HCM), a study has shown.

Vertebral fractures (VFs) are one of the most common fragility fractures, conferring a two- to four-fold increased risk of subsequent hip fracture independent of bone mineral density (BMD). At a scientific symposium, Dr Ronald Man-Yeung Wong, Clinical Associate Professor, Department of Orthopaedics and Traumatology, the Chinese University of Hong Kong, and Dr Sabarul Mokhtar, Senior Consultant Orthopaedic Surgeon of the Hospital Canselor Tuanku Muhriz, Malaysia, discussed how integrating vertebral fracture assessment (VFA) into the fracture liaison service (FLS) could potentially improve vertebral fracture (VF) detection and enable early treatment of very-high-risk patients, permitting timely sequential therapy (eg, beginning with an anabolic agent and followed with a potent antiresorptive agent) to reduce imminent fracture risk, prevent subsequent hip fractures and improve outcomes.

Daily use of topical finasteride 0.25% as monotherapy has resulted in significant increases in hair density and thickness for postmenopausal women with female-pattern hair loss (FPHL) treated in real-world settings, according to a retrospective study.

Use of antithrombotic agents at admission does not increase the risk of in-hospital mortality in patients with acute upper gastrointestinal bleeding (UGIB), according to a study, noting a protective trend overall and significant protection in antiplatelet users and nonvariceal bleeding.

Adding carboplatin to doxorubicin and cyclophosphamide, followed by taxane therapy, results in significant improvement in event-free survival (EFS) among patients with early-stage triple-negative breast cancer (TNBC), as shown in the PEARLY trial.

A pooled analysis of data from five studies shows that a shorter time-restricted eating (TRE) window leads to greater weight loss.