Triglyceride-glucose index linked to incidence of hypertension

The triglyceride-glucose (TyG) index can be used to predict the incidence of hypertension, according to a study involving a population-based sample of Japanese men.

A total of 789 participants developed hypertension over an average follow-up period of 4.96 years. The annual incidence of hypertension increased as the TyG index increased in men (quartile [Q] 1: 4.79 percent; Q2: 6.25 percent; Q3: 7.72 percent; Q4: 9.31 percent) and women (Q1: 3.65 percent; Q2: 5.36 percent; Q3: 5.55 percent; Q4: 6.96 percent).

This association persisted even after adjusting for other risk factors among men (Q2: hazard ratio [HR], 1.39, 95 percent confidence interval [CI], 0.99–1.93; Q3: HR, 1.44, 95 percent CI, 1.03–2.01; Q4: HR, 1.79, 95 percent CI, 1.27–2.52; p=0.001 for trend) and women (Q2: HR, 1.02, 95 percent CI, 0.74–1.40; Q3: HR, 1.04, 95 percent CI, 0.75–1.41; Q4: HR, 1.02, 95 percent CI, 0.74–1.42; p=0.882 for trend).

In this population-based retrospective cohort study, the authors used annual health checkup data from residents of Iki City, Nagasaki Prefecture, Japan. A total of 2,600 participants without hypertension at baseline were included in the analysis.

The TyG index was classified as Q1 (<8.08), Q2 (8.09–8.43), Q3 (8.44–8.84), and Q4 (≥8.85) for men and as Q1 (<7.89), Q2 (7.9–8.22), Q3 (8.23–8.54), and Q4 (≥8.55) for women.