Hepatitis B Differential Diagnosis

Last updated: 07 August 2025

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Differential Diagnosis

Specific serologic testing identifies the different types of viral hepatitis (eg Hepatitis A, C, and E). Viral diseases such as yellow fever, Epstein-Barr virus, cytomegalovirus, HIV, rubella, rubeola, coxsackie B, adenovirus, herpes simplex, and herpes zoster may be considered as alternative diagnoses in patients suspected of HBV infection. 

Non-viral diseases such as leptospirosis, toxoplasmosis, alcoholic hepatitis, autoimmune hepatitis, drug-induced hepatitis or liver injury, toxic hepatitis, cirrhosis, HCC, and Wilson disease should likewise be ruled out.