Systemic Lupus Erythematosus Differential Diagnosis

Last updated: 08 July 2025

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Differential Diagnosis

Conditions that mimic systemic lupus erythematosus that need to be ruled out are the following:

  • Human Immunodeficiency Virus (HIV) infection
  • Drug-induced lupus
  • Early rheumatoid arthritis 
  • Fibromyalgia with positive ANA 
  • Idiopathic thrombocytopenic purpura 
  • Other vasculitides 
  • Sjogren’s syndrome 
  • Scleroderma/systemic sclerosis
  • Rosacea
  • Mixed connective tissue disease