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HIV tied to poor outcomes, death in patients with variceal GI bleeding

29 May 2026

HIV-positive patients with variceal upper gastrointestinal bleeding (VUGIB) may experience worse clinical outcomes and poor survival, according to a study.

HIV tied to poor outcomes, death in patients with variceal GI bleeding

29 May 2026

96-week PULSAR data support aflibercept 8 mg for nAMD

29 May 2026 bởi

Updated results from the phase III PULSAR trial show that intravitreal (IVT) aflibercept 8 mg, when administered at extended dosing intervals of up to 20 weeks, led to visual gains and anatomic improvements comparable to the 2-mg dose, with no new safety concerns over 96 weeks, in treatment-naïve individuals with neovascular age-related macular degeneration (nAMD).

96-week PULSAR data support aflibercept 8 mg for nAMD

29 May 2026

Depression linked to earlier treatment intensification in T2D

29 May 2026

For individuals with type 2 diabetes (T2D) who are initiating oral glucose-lowering monotherapy, a history of clinically diagnosed depression is associated with earlier treatment intensification, such as adding medication or switching to a new drug class, and insulin initiation, as shown in a retrospective study.

Depression linked to earlier treatment intensification in T2D

29 May 2026

Addressing the vaping epidemic: Policy and clinical observations to facilitate cessation

29 May 2026

Vaping has emerged as a significant public health concern, with the WHO estimating over 100 million users globally in 2025, including approximately 15 million adolescents. Misleading marketing and social media advertisements have perpetuated misperceptions about the health risks of vaping, driving uptake particularly among adolescents and young adults. This paper reviews the current evidence, regulatory landscape, and clinical guidance, highlighting that regulatory interventions alone are insufficient, as the heterogeneity of regulatory environments across countries limits the applicability of blanket recommendations. A multipronged approach encompassing expanded pharmacotherapy options is needed. While no standardized vaping cessation guidelines exist, several countries are extrapolating from smoking cessation frameworks and expediting pharmacotherapy approvals, recognizing the urgency of addressing this growing epidemic.

Addressing the vaping epidemic: Policy and clinical observations to facilitate cessation

29 May 2026

Switching DOACs after a breakthrough stroke provides no additional benefit

28 May 2026 bởi

For patients with atrial fibrillation (AF) who sustained an ischaemic stroke while receiving direct oral anticoagulant (DOAC) therapy, switching to another anticoagulation agent does not yield significant improvements in most clinical outcomes compared with staying on the same agent, according to the results of an emulated target trial.

Switching DOACs after a breakthrough stroke provides no additional benefit

28 May 2026

Psychiatric comorbidities in SUDs vary by sex

28 May 2026

Psychiatric comorbidities for various substance use disorders (SUDs) tend to differ by sex, according to a cross-sectional study.

Psychiatric comorbidities in SUDs vary by sex

28 May 2026

Personalized fMRI-guided TMS may improve PTSD symptoms

28 May 2026 bởi

A personalized functional (f)MRI-guided transcranial magnetic stimulation (TMS) that focuses on threat neurocircuitry lowers amygdala threat reactivity and alleviates long-term symptoms of post-traumatic stress disorder (PTSD), reports a study.

Personalized fMRI-guided TMS may improve PTSD symptoms

28 May 2026

Low, high BMI tied to impairments in daily activities

28 May 2026 bởi

Individuals with overweight or obesity, as well as those who are underweight, are predisposed to limitations in activities of daily living (ADL), reveals a study.